Precise, affordable microfluidics research devices
Researchers at Cranfield University are using Ultimaker 3D printers to develop some of the cheapest customizable microfluidics ever made that are delivering results which will impact fields such as medicine and space research.
“Before, we were making parts from machined metal or wood. Each one would take a couple of days and it was hugely more expensive. Now, our Ultimaker 2+ is even outperforming more expensive specialist microfluidics production machines.”
Matthew Partridge, Research Fellow, Cranfield University
Cranfield University – Introduction
Microfluidics are a branch of technology which focus on the manipulation of very small samples of liquids, often about the size of a drop of water. You’ll find it used in medical diagnostics, DNA chips and even research in outer space – anywhere that it’s only possible or easier to use tiny samples. At the Centre for Engineering Photonics at Cranfield University in the UK, Matthew’s team of researchers is working on developing optical sensors for these uses. But producing microfluidics devices from scratch can be expensive, so the team started experimenting with using 3D printing back in 2014. Since then they have published their research showing how they used an Ultimaker 2+ 3D printer and materials to create viable microfluidics devices, reducing their production costs and discovering lots of other benefits of having a 3D printer in the lab.
Before using an Ultimaker 3D printer, the Cranfield University team relied on a full-time technician to make the unique devices needed for experiments. Matthew notes, “Materials costs dropped massively after moving to FDM. Before we were making things out of steel, aluminium, PTFE, plus the cost of the technician time.”
The first step to creating the microfluidics devices is using 3D design software. A student will do a rough design first and print it to validate the overall idea. Then they produce iterations to check each property of the device which will be needed in testing, making changes and printing a new iteration each time. The team use a 0.4 mm nozzle on the Ultimaker 2+ to achieve features down to approximately 20 microns
Reduced production costs not only save budget, but as the price of further iterations is now so low, there is no longer a barrier to achieving the absolute perfect design. This means that at a lower cost, the lab is achieving better results than ever. Their Ultimaker 2+ is running nearly non-stop 24 hours a day and it’s even outperforming a specialist 3D printer for microfluidics devices, achieving smaller channels in the Ultimaker printed devices. The team has also benefited from having a convenient tool to print anything else they need at short notice, like a laser mount or a visualization aid for any project
Cost and Time Saved using 3D Printing
The cost of printing a microfluidics device has been reduced significantly compared to without a 3D printer, paying for a technician and machining metal parts. The team still have their technician but he now gets to focus his time on larger projects instead of easy to solve problems around the lab, bringing benefits elsewhere
Ultimaker 3D printers
|Cost per hour £15||Cost per hour £0.20|
|Cost per device –||Cost per device £0.08|
The cost of printing a microfluidics device has been reduced significantly compared to without a 3D printer, paying for a technician and machining metal parts. The team still have their technician but he now gets to focus his time on larger projects instead of easy to solve problems around the lab, bringing benefits elsewhere.
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